SRY protein function in sex determination: thinking outside the box
- 8 December 2011
- journal article
- research article
- Published by Springer Nature in Chromosome Research
- Vol. 20 (1) , 153-162
- https://doi.org/10.1007/s10577-011-9256-x
Abstract
Even though the mammalian sex-determining gene Sry has been intensively studied for the two decades since its discovery, the regions outside the conserved HMG box DNA-binding domain have received less attention due to a lack of sequence conservation and of obvious structural/functional motifs. Here, we summarize the available evidence for function beyond the HMG box, identify the known and postulated biochemical functions of the non-HMG-box domains in sex determination, and present possible explanations for the puzzling diversity of these non-HMG-box domains.Keywords
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