Platinum and Palladium Complexes Containing Ethylenediamine Derivatives as Carrier Ligands and Their Antitumor Activity.
- 1 January 1994
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 42 (3) , 702-703
- https://doi.org/10.1248/cpb.42.702
Abstract
We prepared new antitumor active platinum complexes containign N, N'-bis(2-chloroethyl)ethylenediamine (ClEn) as an alkylating carrier ligand in order to obtain increased antitumor effects. Some of the platinum complexes synthesized showed enhanced antitumor activity. However, palladium(II) complexes containing ClEn were inactive against L1210 and P388.Keywords
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