Level of Macrophage Induction During Tumor Growth: Primed or Activated?

1 January 1983

journal article
research article
Published by Taylor & Francis in Immunological Communications

Vol. 12 (3) , 285-290
https://doi.org/10.3109/08820138309050750

Abstract

The activation level of thioglycolate (TG)-elicited peritoneal macrophages (Mø) from normal and fibrosarcoma-bearing BALB/c mice was investigated. Lipopolysaccharide was used to distinguish in vitro levels of Mø activation. The results of cytotoxicity assays, which measured nonspecific killing of P815 tumor cells by activated Mø, indicated that tumor-bearing host Mø were primed in situ while normal host Mø remained in a resting state. This level of Mø induction may contribute to the resulting tumor-bearing host T cell immune hyporesponsiveness.

This publication has 10 references indexed in Scilit:

Studies on the antibody-dependent cell-mediated cytotoxicity (ADCC) of thioglycollate-stimulated and BCG-activated peritoneal macrophages
Cellular Immunology, 1981
DIFFERENCES IN ANTIBODY-DEPENDENT CELLULAR CYTO-TOXICITY AND ACTIVATED KILLING OF TUMOR-CELLS BY MACROPHAGE CELL-LINES
1981
THE PARADOXICAL EFFECTS OF THIOGLYCOLLATE-INDUCED MACROPHAGES ON THE GROWTH OF B-16 MELANOMA-CELLS INVIVO AND INVITRO
1980
Activation of Macrophages Assessed by in Vivo and in Vitro Tests
Published by Springer Nature ,1980
Enhancing and suppressive effects of macrophages on T-lymphocyte stimulation in vitro
Cellular Immunology, 1979
Reversal of macrophage-augmented MLR reactivity by tumor-induced splenic suppressor T cells and their soluble factor(s)
Cellular Immunology, 1979
In vitro immune blastogenesis during contact sensitivity in tumor-bearing mice
Cellular Immunology, 1978
Suppressor Cell Activity in Tumor-Bearing Mice
The Journal of Immunology, 1978
SUPPRESSOR CELL ACTIVITY IN TUMOR-BEARING MICE .1. DUALISTIC INHIBITION BY SUPPRESSOR T-LYMPHOCYTES AND MACROPHAGES
1978
Macrophage regulation of the T-cell allogeneic response during tumor growth
Cellular Immunology, 1978