Disulfide Bonds of Human IgM: Differential Sensitivity to Reductive Cleavage
- 1 July 1973
- journal article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 2 (4) , 433-438
- https://doi.org/10.1111/j.1365-3083.1973.tb02052.x
Abstract
Two Waldenström Microglobulins were reduced with increasing amounts of dithiothreitol ranging from 0.25 to 2.0 mM. Disruption of intersubunit, interchain and μ‐J chain disulfide bonds was measured by determining the amount of IgMs, μ chains and J chains released at a given DTT concentration. Intersubunit bonds were most labile, while S‐S bonds linking μ and J chains were most resistant to reductive cleavage.This publication has 12 references indexed in Scilit:
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