ANDROGEN LEVELS DURING CYPROTERONE ACETATE AND ETHINYL OESTRADIOL TREATMENT OF HIRSUTISM

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Abstract
Androgen levels were measured before and during 12 mo. of treatment with cyproterone acetate (50 mg, 5th to 16th day of cycle) and ethynyl estradiol (50 .mu.g, 5th to 26th of cycle) in 26 patients suffering from dysfunctional hirsutism. Patients were included in whom androgen levels after a dexamethasone suppression test fell above the range found in normal non-hirsute women on dexamethasone. Of the patients, 80% showed a substantial improvement of their Ferriman and Gallwey score after 12 mo. of treatment. During the treatment the mean level of testosterone was 64%, androstenedione 55%, testosterone-estradiol binding globulin 365%, apparent free testosterone 30%, dihydrotestosterone 74%, 5-androstanediol 43%, dehydroepiandrosterone 44%, 5-androstenediol 67% and dehydroepiandrosterone sulfate 74% of basal levels. This treatment is effective both clinically and biochemically in reducing hyperandrogenism.