MECHANISM OF DESTRUCTION OF BRUGIA-MALAYI MICROFILARIAE INVITRO - THE ROLE OF ANTIBODY AND LEUKOCYTES

  • 1 January 1982
    • journal article
    • research article
    • Vol. 39  (3) , 225-236
Abstract
Human and monkey [Macaca irus and M. mulatta] leukocytes in serum from previously patent B. malayi infected monkeys adhered to and caused cytotoxicity to microfilariae of B. malayi in vitro. The phenomenon also occurred in human serum from confirmed cases of bancroftian and Malayan elephantiasis. Adherence of leukocytes was not seen in serum from uninfected monkeys, monkeys with patent B. malayi infection and serum from rats infected with Breinlia booliati but now amicrofilaremic. Immune serum failed to promote adherence of leukocytes to L3 of B. malayi. The activity was lost when the serum was either incubated with Protein A-bearing Staphylococcus aureus or heat inactivated at 56.degree. C for 30 min. Light microscopic and EM observations regarding the type of adhering cells and sequence of events following adherence are described.

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