THE RÔLE OF THE ANTERIOR PITUITARY IN ADRENALINE HYPERGLYCEMIA AND LIVER GLYCOGENOLYSIS

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Abstract
Adrenaline infused intraven. at the rate of 0.0035 mg./kg./min. for 5 min. produced a marked hyperglycemia in normal dogs. Adrenaline infused intraven, at the rate of 0.0035 mg./kg./min. for 5 min. produced only a slight hyperglycemia in hypophysectomized dogs. This failure of hypophysectomized dogs to respond to adrenaline with a marked hyperglycemia occurred despite the presence of ample liver glycogen stores. Fasted normal dogs with much smaller liver glycogen content responded to adrenaline with a far greater hyperglycemia than the hypophysectomized. The response of neurohypophysectomized dogs, with intact ant. pituitary, to the hyperglycemic action of adrenaline was similar to normal dogs. In the absence of the ant. pituitary the liver glycogen was less readily mobilized by adrenaline.