The origin of a human chorionic gonadotropin β-subunit-core fragment excreted in the urine of patients with cancer
- 1 July 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 112 (3) , 415-422
- https://doi.org/10.1530/acta.0.1120415
Abstract
Immunoreactive human Chorionic Gonadotropin (hCG), its subunits and hCG.beta.-core fragment were analyzed, using Sephadex G-100 chromatography, in urine and tumour extracts from four patients with cancer. These patients were selected for investigation because they were exercising proportional large amounts of the hCG.beta.-core fragment in their urine. Although 30-85% of the total immunoreactive urinary hCG was hCG.beta. fragment, traces of the fragment (2% of total hCG) were found in only two of the tumours and none in the other two. The predominant molecular form of the hCG in the tumours was intact free .beta.-subunit of hCG. The conclusion is that the hCG.beta.-core fragment found in the urine of some patients with cancer is not a secretion product of the tumours. This fragment is very likely a peripheral degradation product of the free .beta.-subunit of hCG which is secreted by the tumours.This publication has 11 references indexed in Scilit:
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