Effects of Time and Duration of Progesterone Administration on Mammary Tumours Induced by 7,12-Dimethylbenz(a)Anthracene in Sprague-Dawley Rats
Open Access
- 1 January 1973
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 27 (1) , 63-71
- https://doi.org/10.1038/bjc.1973.8
Abstract
A reduction in tumour yield was apparent when progesterone administration was begun 25 days before feeding 7,12-dimethylbenz(a)anthracene (DMBA). This effect was most obvious when the duration of hormone administration was brief. Continuation of progesterone for some time after feeding DMBA caused a progressive diminution of the inhibitory effect, and 135 days of continuous hormone treatment entirely abolished the effects of 25 days pretreatment with the hormone. In contrast, when progesterone injections were begun 2 days after feeding DMBA, there was a trend towards enhancement of tumour yield. Continuous hormone administration appeared more effective than shorter treatment regimens.Keywords
This publication has 3 references indexed in Scilit:
- The Uptake of Progesterone by the Uterus of the Pregnant Rat in Vivo and Its Relationship to Cytoplasmic Progesterone-Binding ProteinEndocrinology, 1972
- Inhibition of Tumor Induction in Chemical Carcinogenesis in the Mammary Gland1Published by S. Karger AG ,1970
- Three Types of Mammary Tumour Induced in Rats by Feeding with DMBABritish Journal of Cancer, 1964