Modulation of the induction of nitric oxide synthase by eicosanoids in the murine macrophage cell line J774
Open Access
- 1 November 1992
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 107 (3) , 640-641
- https://doi.org/10.1111/j.1476-5381.1992.tb14499.x
Abstract
The effect of eicosanoids on the induction of nitric oxide synthase in the murine macrophage cell line J774 has been studied. We found that prostaglandin E2 (PGE2) and iloprost (a stable analogue of prostacyclin) both at nanomolar concentrations inhibited the lipopolysaccharide stimulated induction of NO synthase. In contrast PGF2α, U46619, a stable analogue of thromboxane A2, leukotrienes B4 and C4 had no effect. These data demonstrate that the l-arginine: NO pathway in macrophages may be modulated by prostanoids.Keywords
This publication has 9 references indexed in Scilit:
- Glucocorticoids inhibit the induction of nitric oxide synthase in macrophagesBiochemical and Biophysical Research Communications, 1990
- Interdependence of tumor necrosis factor, prostaglandin E2, and protein synthesis in lipopolysaccharide‐exposed rat Kupffer cellsEuropean Journal of Biochemistry, 1990
- Nitric oxide: A cytotoxic activated macrophage effector moleculeBiochemical and Biophysical Research Communications, 1988
- Release of tumor necrosis factor-alpha from macrophages. Enhancement and suppression are dose-dependently regulated by prostaglandin E2 and cyclic nucleotides.The Journal of Immunology, 1988
- Interferon‐γ and tumor necrosis factor induce the L‐arginine‐dependent cytotoxic effector mechanism in murine macrophages*European Journal of Immunology, 1988
- Leukotrienes and Prostaglandins Mutually Govern the Antitumor Potential of MacrophagesProceedings in Life Sciences, 1987
- Effects of various inhibitors of arachidonic acid oxygenation on macrophage superoxide release and tumoricidal activity.The Journal of Immunology, 1985
- Evidence for two sources of arachidonic acid for oxidative metabolism by mouse peritoneal macrophages.Journal of Biological Chemistry, 1982
- Macrophage-mediated tumor cell killing: regulation of expression of cytolytic activity by prostaglandin E.The Journal of Immunology, 1981