Both C3a and C3adesArg Regulate Interleukin‐6 Synthesis in Human Peripheral Blood Mononuclear Cells
Open Access
- 1 June 1998
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 177 (6) , 1622-1628
- https://doi.org/10.1086/515316
Abstract
Synthesis of complement components is part of the acute-phase response. Interleukin-6 (IL-6) is a critical mediator of the acute-phase response during infections and injuries. Plasma levels of C3a and IL-6 have been proposed as prognostic indicators in sepsis and trauma. The effects of C3a and C3adesArg on IL-6 gene expression and protein production in human peripheral blood mononuclear cells (PBMC) were investigated. Neither C3a nor C3adesArg alone induced detectable IL-6 protein or mRNA levels. However, C3a and C3adesArg affected endotoxin-induced IL-6 synthesis in a dose-dependent manner. In nonadherent PBMC, C3a or C3adesArg suppressed, while in adherent PBMC, C3a or C3adesArg enhanced IL-6 protein and mRNA levels. These results suggest that C3a and C3adesArg may provide a control mechanism of acute-phase responses by enhancing IL-6 synthesis in adherent monocytes at local inflammatory sites and by inhibiting IL-6 synthesis in circulating monocytes.Keywords
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