A New Pyridazine Series of GABAA α5 Ligands
- 23 August 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 48 (19) , 6004-6011
- https://doi.org/10.1021/jm050249x
Abstract
MEDLINE?? is the source for the MeSH terms of this document.Screening of the Merck compound collection identified 6 as an unusually simple, low molecular weight hit with moderate affinity for GABAA receptors. The structural novelty of 6, compared to our advanced series of GABAA ??5 inverse agonists, made it an attractive molecule for further exploration. This paper will describe the evolution of 6 into a new series of ligands with nanomolar affinity and functional selectivity for GABAA ??5 receptor subtypesKeywords
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