Nucleic Acid Changes in Sarcoma 180 Following Administration of Aminopterin.

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Abstract
Summary The pentose nucleic acid (PNA) and desoxypentose nucleic acid (DNA) content of sarcoma 180 tumors has been determined in mice receiving aminopterin and in controls. The chief alteration associated with aminopterin administration was an increase in the ratio of PNA to DNA due to a reduction in the relative DNA content. Tumors which had been serially transplanted into aminopterin-treated mice, when used as inocula, showed no difference when compared to stock tumors in their subsequent response to aminopterin.