RESTORATION OF DIMINISHED T-CELL FUNCTION IN ADJUVANT INDUCED DISEASE BY METHOTREXATE - EVIDENCE FOR 2 POPULATIONS OF SPLENIC T-CELL SUPPRESSORS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 3  (4) , 346-354
Abstract
Diminished [rat] splenic T[thymus-derived]-cell function, as measured by response to phytohemagglutinin and concanavalin A, was noted only during the active phase of adjuvant induced disease. This diminished function is due to at least 2 types of suppressor cells: cells which adhere to glass but not plastic and which are sensitive to methotrexate in vitro, and cells which adhere to plastic and glass, and which are relatively insensitive to methotrexate in vitro. Methotrexate treatment in vivo inhibits adjuvant induced disease and is associated with absence of both types of suppressor cells in the spleen.