Hypersensitivity to molybdenum as a possible trigger of ANA-negative systemic lupus erythematosus.
- 1 June 1994
- journal article
- case report
- Published by Elsevier in Annals of the Rheumatic Diseases
- Vol. 53 (6) , 403-405
- https://doi.org/10.1136/ard.53.6.403
Abstract
After implantation of two metal plates a 24 year old woman developed fever of unknown origin and successively more symptoms of an ANA-negative systemic lupus erythematosus (SLE). These symptoms resolved after removal of the plates and recurred during patch testing of the metal components, which showed a reaction to molybdenum. A lymphocyte transformation test indicated a delayed-type hypersensitivity to molybdenum. Subsequent progressive flare ups of SLE appeared without molybdenum reexposure. This is the first report suggesting the existence of a hypersensitivity to molybdenum, which may act as another environmental trigger for SLE.Keywords
This publication has 13 references indexed in Scilit:
- Systemic lupus erythematosus: clinical and immunologic patterns of disease expression in a cohort of 1,000 patients. The European Working Party on Systemic Lupus Erythematosus.1993
- Systemic Lupus ErythematosusMedicine, 1993
- B-cell responses in autoimmune diseasesCurrent Opinion in Immunology, 1992
- Systemic Lupus ErythematosusAnnals of Internal Medicine, 1991
- Molybdenum: An Essential Trace Element in Human NutritionAnnual Review of Nutrition, 1988
- The 1982 revised criteria for the classification of systemic lupus erythematosusArthritis & Rheumatism, 1982
- Fever of Undetermined OriginMedicine, 1982
- Antibodies to sm in patients with systemic lupus erythematosus. correlation of sm antibody titers with disease activity and other laboratory parametersArthritis & Rheumatism, 1981
- Serological Findings in Patients with “ANA-Negative” Systemic Lupus ErythematosusMedicine, 1981
- Exacerbation of lupus erythematosus following splenectomy in “idiopathic” thrombocytopenic purpura and autoimmune hemolytic anemiaThe American Journal of Medicine, 1956