Effects of Positive End‐Expiratory Pressure on Renal Function
- 1 October 1978
- journal article
- Published by Wiley in Acta Anaesthesiologica Scandinavica
- Vol. 22 (5) , 508-514
- https://doi.org/10.1111/j.1399-6576.1978.tb01331.x
Abstract
The effects were studied positive end-expiratory pressure (PEEP) on renal function in eight patients with acute respiratory failure, requiring mechanical ventilation. On application of PEEP + 10 cm H2O, central venous pressure increased, systolic blood pressure decreased, urine flow and PAH-clearance were reduced, while inulin clearance remained stable. There was a marked increase in fractional sodium reabsorption and a concurrent decrease in fractional osmolal excretion. Fractional free-water clearance and the ratio UOsm/POsm did change.Keywords
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