Urography with Low-Osmolality Contrast Media
- 1 September 1982
- journal article
- research article
- Published by Wolters Kluwer Health in Investigative Radiology
- Vol. 17 (5) , 494-500
- https://doi.org/10.1097/00004424-198209000-00010
Abstract
The pharmacokinetics and urinary excretion characteristics of sodium diatrizoate, the new low-osmolality contrast medium iopamidol, a nonionic monomer, and ioxaglate, a monoacidic dimer, were compared. Using rabbits, experimental urography was performed at a dose of 450 mg I/kg. The lowosmolality contrast medium showed significantly higher urinary iodine concentration, lower urinary flow rate, and a roughly equivalent total iodine excretion rate as diatrizoate. Low-osmolality contrast media would thus have significant advantages over currently available media in clinical urography because of these excretion characteristics.Keywords
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