The Effect of Clofibrate on Thrombocyte Adhesivity and Some Coagulation Parameters

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Abstract
Nine women about 80 years of age and in a satisfactory and stable clinical state without recent thrombotic processes submitted to a double blind trial of oral treatment with clofibrate, clofibrate + androsterone or corn oil. Each treatment or non-treatment period was 8 weeks. No significant response to treatment was elicited in 6 tests of the liver function, 3 of the lipid metabolism and 2 supplementary tests. The cholesterol concentration in serum decreased when clofibrate-containing preparations were given as did the concentration of fibrinogen in plasma during the clofibrate + androsterone period (and possibly also during clofibrate). The prothrombin concentration, thrombin generation, and thrombocyte adhesivity were unaffected. Toxic side-reactions were not registered.