RESPONSE OF INFANTS TO TRIVALENT POLIOVIRUS VACCINE (SABIN STRAINS)

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Abstract
An initial dose of live, oral, trivalent poliovirus vaccine was fed to 137 infants at the age of 6 to 8 weeks. Eight weeks later they were given a second dose. They received a third dose at the age of 1 year and a fourth dose 8 weeks later. Efficacy was judged by antibody levels in serum samples. Results showed that general sero-immunity was conferred by this program. Analysis of the data revealed that a significant response followed the first two doses but that antibody levels for type 1 were not maintained at the age of 1 year. Response to the third dose was prompt and significant for type 1. The fourth dose apparently was unnecessary. There was some evidence of interference by maternal antibodies. However, their presence, even in high concentrations, did not preclude effective immunization.

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