Abstract
EDITOR - K S Channer1 and other correspondents2 seem to misunderstand the results of clinical trials of thrombolytic agents. In 17 000 patients in the second international study of infarct survival (ISIS-2) the odds of dying were reduced by 25% by streptokinase compared with placebo (figure).3 With such large numbers the confidence intervals, which indicate where the “true” result is to be found with 95% certainty, are narrow. Odds ratios and 95% confidence intervals for death within 35 days after …

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