Chiasma derived genetic lengths and recombination fractions: a 46, XY, t(9; 10) (p22; q24) reciprocal translocation

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Abstract
Chiasma distribution data on chromosomes 1, 2 and 9 from a reciprocal translocation carrier with a 46, XY, t(9; 10) (p22; q24) karyotype were used to calculate genetic distances and recombination fractions for chromosome segments corresponding to the major mitotic bands and for intervals between the centromeres and points at 10% intervals along the chromosome arms. These values were compared with those from control males with normal karyotypes. The translocation showed a marked increase in crossing-over in one specific region of chromosome 9 and, in addition, there was evidence of interchromosomal effects in chromosomes 1 and 2.