Endoscopic evaluation of slow-release potassium chloride preparations

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Abstract
In a double-blind, randomized, placebo-controlled clinical trial, 30 healthy subjects took 1 of 2 KCl preparations or placebo 3 times a day for 1 wk with concomitant oral glycopyrrolate dosing. The upper digestive tract was endoscopically examined immediately before and after the treatment period. One subject in both of the KCl treatment groups and 6 subjects in the placebo group developed submucosal lesions. All lesions were minor and of limited clinical significance. There may be reason to believe that glycopyrrolate plays a role in the production of such lesions. If so, the concomitant use of glycopyrrolate in clinical trials of KCl preparations may cloud the results of such studies.

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