Effects of Synthetic Parathyroid Hormone on Vascular Beds of Dogs

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Abstract
Blood flow rates and vascular resistance in dogs were determined in 14 tissues with 15 ± 2 μm radioactive microspheres (141Ce, 51Cr, 85Sr). Intravenous injection of synthetic bovine parathyroid hormone containing the NH2-terminal 1–34 amino acids [bPTH-(1–34)] at the dose of 10 USP units/kg body weight produced hypotension and increases in blood flow rate and decreases in resistance in kidney cortex, kidney medulla, heart, liver, stomach and pancreas at ½ and 2 min after injection. 4U bPTH-(1–34)/kg body weight produced less vasodilation. Saline injection had no effect on the tissues studied.