PROMOTION OF BENIGN HYPERPLASTIC LESIONS IN HAMSTER-CHEEK POUCH BY MEMBRANE LABELIZING AGENTS AND CALCIUM-ION - EVIDENCE THAT INTRACELLULAR CALCIUM-INDUCED RELEASE FROM GROWTH-CONTROL IS AN OBLIGATORY PRELIMINARY STAGE OF TUMOR PROMOTION
- 1 January 1980
- journal article
- research article
- Vol. 27 (2) , 277-292
Abstract
Ca ion, ionophore 23187 and the membrane labilizing agents Triton X-100, trypsin and phospholipase C promoted benign hyperplastic lesions (BHL) but only rarely advanced tumors in hamster cheek pouch mucosa, which had been initiated with 7,12-dimethylbenz(a)anthracene. Retinyl acetate (RA) and croton oil markedly promoted BHL and advanced tumors. Pathways modulated by intracellular Ca apparently cause initiation-stabilized release from growth control thus the promotion of BHL, whereas additional mechanisms are required for the progression of BHL to more advanced tumors. Some Ca-modulated systems which could be involved in the promotion of BHL are discussed in the light of published literature.This publication has 15 references indexed in Scilit:
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