THE ABNORMAL POLYPEPTIDE CHAINS IN A NUMBER OF HAEMOGLOBIN VARIANTS

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Abstract
The identity of the abnormal polypeptide chain, in a number of hemoglobin variants, has been determined by a microscale hybridization procedure used in conjunction with analysis in starch gel. Three specimens of Hb-D, three of Hb-J and two specimens of Hb-N have been shown to have abnormal [beta]-chains, while specimens of Hb-and Hb-Norfolk have abnormal [alpha]-chains. Two further examples of Hb-G, with abnormal [beta]-chains and one with abnormal [alpha]-chains are reported. The possible significance of these findings is discussed with reference to the relatively low frequency of hemoglobins with abnormal [alpha]-chains, compared with those with abnormal [beta]-chains.