Common clonal T-cell origin in a patient with T-prolymphocytic leukaemia and associated cutaneous T-cell lymphomas
- 6 February 2003
- journal article
- case report
- Published by Wiley in British Journal of Haematology
- Vol. 120 (3) , 488-491
- https://doi.org/10.1046/j.1365-2141.2003.04072.x
Abstract
Summary. An unusual course was observed in a patient with indolent T‐prolymphocytic leukaemia (T‐PLL) who subsequently developed mycosis fungoides (Mf), lymphomatoid papulosis (LyP) and cutaneous CD30+ anaplastic large cell lymphoma (ALCL). Polymerase chain reaction analysis demonstrated identical monoclonal T‐cell receptor‐β and ‐γ gene rearrangements in all the different clinical entities. Furthermore, cytogenetic studies revealed the same aberrant clone with trisomy of chromosome 8 in T‐PLL and ALCL cells. This unique observation suggests that in T‐PLL, the leukaemic cells might undergo secondary transformation, subsequently resulting in different phenotypes of cutaneous T‐cell lymphoma.Keywords
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