TWO COMPARISONS OF THE ANALGESIC ACTIVITY OF ORALLY ADMINISTERED PENTAZOCINE, DIHYDROCODEINE AND PLACEBO

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Abstract
SUMMARYTwo double-blind between-patient comparisons of the analgesic activity of orally administered pentazocine 50 mg, dihydrocodeine 60 mg and placebo are described, which involved 99 patients in “severe” or “moderate” pain, mainly of skeletal origin, and 103 patients in “severe” or “moderate” pain predominatly of postoperative origin. In both studies pain was assessed by a single observer prior to and 1 hour after the administration of a single dose of one of the test preparations. Both active drugs were significantly superior to placebo, and in both studies a firm trend showed pentazocine to be more effective than dihydrocodeine which was in turn more effective than placebo. Drowsiness more commonly followed pentazocine administration, but nausea and vomiting more commonly followed dihydrocodeine.

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