Direct influence of morphine on the release of arachidonic acid and its metabolites
- 24 May 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 323 (1-2) , 163-165
- https://doi.org/10.1016/0014-5793(93)81471-b
Abstract
The influence of 10−10–10−6 M morphine on the release of [3H]arachidonic acid and its metabolites ([3H]AAM) from prelabeled resident peritoneal murine macrophages was investigated. Morphine enhanced [3H]AAM release from A23187‐ and LPS‐stimulated macrophages, as well as the basal release of [3H]AAM. Dose‐response curves showed a maximum at 10−8 M morphine. Naloxone had no effect on morphine enhancement of [3H]AAM release. These results are in agreement with the hypothesis that [3H]AAM may be involved in the effects of morphine.Keywords
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