Major Histocompatibility Complex Genes and Susceptibility to Systemic Lupus Erythematosus in Northern India
- 1 October 1993
- journal article
- research article
- Published by SAGE Publications in Lupus
- Vol. 2 (5) , 313-314
- https://doi.org/10.1177/096120339300200506
Abstract
Fifty-eight patients with systemic lupus erythematosus (SLE) from Northern India were tissue typed for HLA class I and II antigens. The results revealed an appreciable increase of HLA-DR4 (37.5%) among patients compared with controls (17.9%), P < 0.03. Additionally, haplotype B8-DR3 was encountered frequently in the patient group. The findings suggest an important role of MHC genes in influencing susceptibility to SLE.Keywords
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