Stereoselective Synthesis of Four Stereoisomers of β-Methoxytyrosine, a Component of Callipeltin A
- 23 March 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 70 (8) , 3120-3126
- https://doi.org/10.1021/jo047876z
Abstract
Callipeltin A is a novel cyclic depsipeptide that selectively inhibits the cardiac sodium/calcium exchanger and is therefore of interest as a regulator of myocardial contractility. The stereochemistry of β-methoxytyrosine, one of the amino acids contained within the marine natural product, could not be determined. In an effort to elucidate the stereochemistry of this moiety, a stereoselective synthesis of four stereoisomers of β-methoxytyrosine from (S)- and (R)-serine was accomplished.Keywords
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