Paroxysmal Cold Hemoglobinuria: Transmission and Scanning Electron Microscopy Features of Erythrocytes

Abstract
Djaldetti, Meir, Elion, Dorith, Bessler, Hana, and Fishman, Pnina: Paroxysmal cold hemoglobinuria. Transmission and scanning electron microscopy features of erythrocytes. Am J Clin Pathol 63: 804–810, 1975. The case history of a patient with paroxysmal cold hemoglobinuria of the chronic idiopathic type is reported. The patient showed a marked dependency on the external temperature, with severe hemolytic anemia and hemoglobinuria during the winter. Examination of the erythrocytes with the transmission electron microscope showed abnormal forms identified as ropalocytes, whereas examination with the scanning electron microscope revealed “holes” in the erythrocytes.

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