CONCANAVALIN-A INDUCED INHIBITION OF CELL-MIGRATION IN AFRICAN-GREEN MONKEY KIDNEY CELL-CULTURES

  • 1 January 1977
    • journal article
    • research article
    • Vol. 41  (2) , 147-158
Abstract
The effect of concanavalin A (con A) on the mobility of Vero cells into cell free gaps was examined. The movement of cells into these wounds was inhibited by a 30 min exposure of con A at a concentration of 12.5 .mu.g/ml. The effects of con A on the mobility are dependent on the concentration of the lectin used for treatment and the total amount of time the cells are exposed to a given concentration. The con A inhibition was abrogated by .alpha.-methyl-mannose. The competitive effects of con A inhibition and serum migration stimulation factors were examined. Treatment of the monolayer prior to wounding inhibits as effectively as treatment after wounding, indicating that residual con A on the wound bed which the cells cross was not responsible for the demonstrated inhibition.

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