HISTOCOMPATIBILITY GENES OF MICE .3. H-1 AND H-4, 2 HISTOCOMPATIBILITY LOCI IN FIRST LINKAGE GROUP

  • 1 January 1961
    • journal article
    • research article
    • Vol. 4  (4) , 366-+
Abstract
A new histocompatibility locus, H-4, in the first linkage group of the mouse, has been identified. The gene-order in this linkage group is H-l, c, p, with H-4 very close to p but its position relative to p undetermined. There is 8.5+2.1 per cent crossing over between H-l and c in the heterozygous female, 5.4 + 3.7 per cent in the heterozygous male. At least 4 alleles at the H-l locus have been identified. The distribution of H-l, alleles in various inbred and co-isogenic resistant stocks is shown in Table II. The mean survival of skin grafts made between various co-isogenic strain pairs, differing at H-1, ranges from 32 to 91 days, with a minimum survival of individual grafts of 20 days and a maximum of 124 days. Ovarian grafts between the same strain pairs show much longer survival. The significance of these results for estimates of gene numbers is discussed; the higher published estimates are favored.