Chromosomal Studies on Primary Methylcholanthrene-Induced Sarcomas in the Mouse2

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Abstract
Cytological studies of chromosomes have been made on 14 primary fibrosarcomas induced by intramuscular injection of methylcholanthrene. All tumors showed a considerable variability in chromosome number. Ten tumors were characterized by stem lines, which were changed chromosomally and were individually different for each neoplasm. These results agree with existing data on transplanted methylcholanthrene-induced sarcomas. Four tumors contained cells with the normal diploid number of 40 chromosomes as their dominating stem line and did not show any detectable structural modifications. The difference between tumors might be due to the fact that they have reached various stages of progression. It also appears that great structural or numerical chromosome changes are not necessary for the development of all tumors.