CHARACTERIZATION OF THE SPONTANEOUS MURINE B CELL LEUKEMIA (BCL1) .3. EVIDENCE FOR MONOCLONALITY BY USING AN ANTI-IDIOTYPE ANTIBODY

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 122  (5) , 1649-1654
Abstract
An anti-idiotypic antibody was raised against the cell surface Ig[immunoglobulin]M of the murine BCL1 tumor cells. This antiserum reacted exclusively with the IgM expressed on the tumor cells and detected a unique population of cells in the spleen and blood of the tumor-bearing mice. When these cells were stimulwted in vitro with [Salmonella typhi] LPS [lipopolysaccharide], they secreted an IgM bearing the same idiotype as the cell surface Ig. These results were discussed in terms of a model for the immunotherapy of a chronic lymphocytic leukemia-like syndrome in mice.