The effects of prostaglandinsE1,F1αandF2αon monosynaptic reflexes

Publisher Website
Google Scholar
Abstract
Experiments, using electrophysiological recording techniques, were carried out to confirm the report that prostaglandins affect spinal reflexes in cats. Ventral root potentials evoked by stimulation of the ipsilateral dorsal root were recorded. Those with a latent period corresponding to a monosynpatic pathway were used primarily in this investigation. Prostaglandin El or lla, 15 dihydroxy-9-oxo-prost-13-enoic acid (3.5-17.8 [mu]g/kg) injected into the aorta reduced the amplitude of monosynaptic responses in 6 out of 10 cats. The effect began about 15 min after injection and lasted over 3 hr. In one cat E1 caused potentiation of the reflex and in 3 cats there was no effect. Prostaglandin F1[alpha] or 9a,lla,15-trihydroxy-prost-13-enoic acid (2.4-3.5 [mu]g/kg) inhibited the monosynaptic response in 4 cats but in one of these a subsequent large dose (19.6 [mu]g/kg) greatly potentiated the reflex. Prostaglandin F2[alpha] 9[alpha], 11a,15-trihydroxy-prost-5,13-dienoic acid (1.4-17.8 [mu]g/kg) injected into the aorta was followed by significant but variable changes in monosynaptic response. In one experiment an intravenous injection (30.3 [mu]g/kg) was followed by a long-lasting potentiation of the reflex response. Prostaglandins, 2 of which were previously identified in cat brain extracts, have pronounced and long-lasting effects on monosynaptic spinal reflexes.

This publication has 6 references indexed in Scilit: