Generalized Hailey-Hailey disease

Abstract
A 60 yr old woman developed a generalized erythroderma. The case history revealed classical symptoms of Hailey-Hailey disease for 17 yr. Light- and electron microscopic investigations confirmed the diagnosis of generalized Hailey-Hailey disease, an extremely rare condition. Additional cases (2) with widespread clinical manifestations were presented. These observations underline the fact that the whole epidermis is genetically disturbed and may react to various insults with suprabasal acantholysis.