Tetronomycin, a novel polyether of unusual structure.
- 1 January 1982
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 35 (2) , 142-150
- https://doi.org/10.7164/antibiotics.35.142
Abstract
Tetronomycin, C34H50O8, isolated from a strain of Streptomyces represents a novel polycyclic ionophore polyether. The crystal structure and absolute configuration were established by X-ray analysis of the mono-O-acetyltetronomycin silver salt. Tetronomycin is the first metabolic polyether which contains a tetronic acid moiety instead of the essential carboxylic acid function. A trisubstituted cyclohexane ring and an interesting molecular conformation of the silver salt represent additional unique structural features. Extensive NMR studies enabled the assignment of chemical shifts and the correlation of the proton and C signals. Tetronomycin exhibits activity against gram-positive bacteria.This publication has 1 reference indexed in Scilit:
- Studies in the biochemistry of micro-organismsBiochemical Journal, 1947