CIRCULATORY REACTIONS OF RATS TRAUMATIZED IN THE NOBLE-COLLIP DRUM

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Abstract
Rats were traumatized according to the method developed by Noble and Collip and data obtained on blood pressure changes, hematocrit and plasma volume, and the capillary circulation in the skin and mesentery. Exposure of 150 g. rats to 600-650 revolutions in the Noble-Collip drum resulted in a lowered blood pressure which in fatal cases persisted below 60 mm. The hematocrit values always showed an increase averaging 12-15% above normal. The total plasma volume usually showed a decrease of about 15%. Rats were protects a with padding over various regions of the body before being drummed. Those animals which had their abdomen well-padded withstood 1000 revolutions without developing fatal shock. The shock-like state being studied, therefore, appears to result largely from direct trauma to the viscera.

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