Metastasis Suppressor Proteins: Discovery, Molecular Mechanisms, and Clinical Application
Open Access
- 1 July 2006
- journal article
- review article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 12 (13) , 3882-3889
- https://doi.org/10.1158/1078-0432.ccr-06-1014
Abstract
Clinically and experimentally, primary tumor formation and metastasis are distinct processes — locally growing tumors can progress without the development of metastases. This observation prompted the hypothesis that the molecular processes regulating tumorigenicity and metastasis areKeywords
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