STUDIES ON ADRENAL INSUFFICIENCY IN DOGS

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Abstract
For comparison with dogs subjected to treatment, or pregnant, tables give results of observations on 34 cf dogs and 39 non-pregnant [female]. Pregnant animals are excluded because the survival period is markedly lengthened by pregnancy. The adrenals were removed in 2 stages with intervals of 1 week-6 mo.; intervals of 1 week gave as good results as longer ones. About f of the dogs lived 4 or 5 to 8 or 9 days after the 2nd adrenalectomy; about 1/10 lived 10-12 days; 2 dogs lived 15 days; about 1/6 survived 4 days or less. The animals recover radidly from the 2nd operation. Generally, with the shorter survivals, the period of normal health and good appetite are relatively less than with longer survivals. Consequently the time the dog still lives after the anorexia, the most characteristic and constant symptom, has declared itself is not very different in most animals, whether the total survival period be long or short. Most dogs died in less than 3 days after definitely refusing food. Other symptoms (vomiting, nervous symptoms, asthenia, etc.) are described. The pathological changes found at autopsy, especially in the gastro-intestinal tube (congestion and hemorrhage in the mucosa, blood in the lumen) and in the pancreas, are indicated and details given in the protocols cited.

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