Biological Networks: The Tinkerer as an Engineer
Top Cited Papers
- 26 September 2003
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 301 (5641) , 1866-1867
- https://doi.org/10.1126/science.1089072
Abstract
This viewpoint comments on recent advances in understanding the design principles of biological networks. It highlights the surprising discovery of “good-engineering” principles in biochemical circuitry that evolved by random tinkering.Keywords
This publication has 31 references indexed in Scilit:
- Negative Autoregulation Speeds the Response Times of Transcription NetworksJournal of Molecular Biology, 2002
- Transcriptional Regulatory Networks in Saccharomyces cerevisiaeScience, 2002
- Network Motifs: Simple Building Blocks of Complex NetworksScience, 2002
- Chromosomal gradient of histone acetylation established by Sas2p and Sir2p functions as a shield against gene silencingNature Genetics, 2002
- Hierarchical Organization of Modularity in Metabolic NetworksScience, 2002
- Network motifs in the transcriptional regulation network of Escherichia coliNature Genetics, 2002
- A Genomic Regulatory Network for DevelopmentScience, 2002
- Control Motifs for Intracellular Regulatory NetworksAnnual Review of Biomedical Engineering, 2001
- A Test Case of Correlation Metric Construction of a Reaction Pathway from MeasurementsScience, 1997
- Intracellular signalling as a parallel distributed processJournal of Theoretical Biology, 1990