Risk Evaluation in a Small Series of Transabdominal Chorionic Villus Sampling

Abstract
Previous reports have suggested that the fetal loss rate with transcervical chorionic villus sampling was high in the initial 100–300 procedures performed. In a consecutive series of 155 patients with first-trimester transabdominal chorionic villus sampling (CVS), we observed a total fetal loss rate of 8.4%, and a loss rate not attributable to induced abortion or cytogenetic abnormality of 3.2%. Our results demonstrate that transabdominal CVS in the first trimester of pregnancy is a safe method of prenatal diagnosis.

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