Toxic Effect of Dimethylnitrosamine in Cows

Publisher Website
Google Scholar
Abstract
Cattle were exposed to both commercial dimethylnitrosamine (DMNA) and herring meal in which DMNA developed during processing and storage. DMNA levels in fish meal were titrated by bioassay and compared with those obtained by analytic chemistry. Accumulation of OMNA started when the dosage exceeded a threshold value of 0.1 mg DMNA/kg body weight. Signs of liver damage became apparent when the dosage was 12-26 mg DMNA/kg. If DMNA was removed from the diet, recovery from the liver damage occurred. Regeneration of liver tissue and neoformation of hepatic veins to replace those lost by obliteration were established. The vessel wall damage extended beyond the liver. The hepatic vein branches especially showed necrosis of the endothelium, edema, and bleeding in the vessel wall itself with subsequent narrowing of the lumen. These veno-occlusive changes caused increased fibrosis of the liver. Tumors were not observed in cattle exposed to DMNA.

This publication has 0 references indexed in Scilit: