Stereochemical fate of the isopropylidene methyl groups of lanosterol during the biosynthesis of isofucosterol in Pinus pinea
- 1 January 1981
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 2,p. 498-502
- https://doi.org/10.1039/p19810000498
Abstract
[26-3H]Lanosterol (16) was administered to Pinus pinea and the [26-3H]isofucosteryl acetate (6) obtained was chemically transformed into [26-3H]cholesterol (13). Compound (13) was incubated with rat-liver mitochondria to yield [3-3H] propionic acid. The data obtained are consistent with a biosynthetic pathway in which the pro-E isopropylidene methyl group of the Δ24-precursor becomes the pro-R isopropyl methyl group in isofucosterol.This publication has 3 references indexed in Scilit:
- Role of 24- and 28-hydroxylated intermediates in the metabolism of β-sitosterol in the insect Tenebrio molitorBiochemical Journal, 1979
- Stereospecific synthesis of Δ24‐sterols labelled on the 26‐ or 27‐methyl groupJournal of Labelled Compounds and Radiopharmaceuticals, 1978
- The Preparation of 24-Keto and 24-Hydroxycholesterol and Certain Derivatives1Journal of the American Chemical Society, 1944