Purine-resistant Drosophila melanogaster result from mutations in the adenine phosphoribosyltransferase structural gene.
- 1 May 1983
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 80 (10) , 2990-2994
- https://doi.org/10.1073/pnas.80.10.2990
Abstract
Mutants of D. melanogaster selected for resistance to purine killing are deficient in adenine phosphoribosyltransferase (APRT; EC 2.4.2.7) activity. Genetic mapping and complementation analysis demonstrate that purine resistance, deficiency of APRT activity, and differences in the isoelectric point of APRT result from alterations at a single locus, Aprt (map position, 3:3.03). The level of APRT activity shows gene dose dependence in Aprt heterozygotes and in flies that are haploid for different Aprt alleles. Drosophila APRT is a dimer composed of apparently identical 23,000-dalton subunits. Aprt may contain the structural gene for APRT.This publication has 14 references indexed in Scilit:
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