Region 4 of σ as a target for transcription regulation
- 8 May 2003
- journal article
- review article
- Published by Wiley in Molecular Microbiology
- Vol. 48 (4) , 863-874
- https://doi.org/10.1046/j.1365-2958.2003.03467.x
Abstract
Bacterial σ factors play a key role in promoter recognition, making direct contact with conserved promoter elements. Most σ factors belong to the σ70 family, named for the primary σ factor in Escherichia coli. Members of the σ70 family typically share four conserved regions and, here, we focus on region 4, which is directly involved in promoter recognition and serves as a target for a variety of regulators of transcription initiation. We review recent advances in the understanding of the mechanism of action of regulators that target region 4 of σ.Keywords
This publication has 75 references indexed in Scilit:
- Protein–Protein and Protein–DNA Interactions of σ70 Region 4 Involved in Transcription Activation by λcIJournal of Molecular Biology, 2002
- Mapping the molecular interface between the σ70 subunit of E. coli RNA polymerase and T4 AsiAJournal of Molecular Biology, 2001
- A multipartite interaction between Salmonella transcription factor σ28 and its anti-sigma factor FlgM: implications for σ28 holoenzyme destabilization through stepwise bindingJournal of Molecular Biology, 2001
- Efficient Inhibition of Escherichia Coli RNA Polymerase by the Bacteriophage T4 AsiA Protein Requires that AsiA Binds First to Free σ70Journal of Molecular Biology, 2000
- Interactions between activating region 3 of the Escherichia coli cyclic AMP receptor protein and region 4 of the RNA polymerase σ 70 subunit: application of suppression genetics 1 1Edited by R. EbrightJournal of Molecular Biology, 2000
- THE ANTI-SIGMA FACTORSAnnual Review of Microbiology, 1998
- Inhibition of Escherichia coli RNA polymerase by bacteriophage T4 AsiAJournal of Molecular Biology, 1998
- Transcription Activation by the Bacteriophage Mu Mor Protein Requires the C-terminal Regions of Both α and σ70 Subunits of Escherichia coli RNA PolymerasePublished by Elsevier ,1996
- A mutant Escherichia coli σ70 subunit of RNA polymerase with altered promoter specificityJournal of Molecular Biology, 1989
- Host-virus interactions in the control of T4 prereplicative transcriptionJournal of Molecular Biology, 1979