A molecular map of the immune response region from the major histocompatibility complex of the mouse

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Abstract
A stretch of 200 kilobases (kb) of DNA from the I region of the mouse major histocompatibility complex was cloned and characterized. It contains the genes for the biochemically defined class II proteins E.alpha., E.beta. and A.beta.. DNA blot analyses suggest that the I region may contain only 6-8 class II genes. Correlation of the molecular map with the genetic map of the I region confines 2 of the 5 I subregions, I-J and I-B, to < 3.4 kb of DNA at the 3'' end of the E.beta. gene where a hotspot for recombination was observed. The I-A and I-E subregions may be contiguous. If so, the I-B and I-J subregions are not encoded in the I region between the I-A and I-E subregions.