Quantitative histochemistry of brain tumors and analogous normal tissue

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Abstract
Quantitative histochemical methods were utilized in the study of 4 brain tumors and their analogous tissues. The activity of lactic dehydrogenase, malic dehydrogenase, phosphohexoisomerase, and glucose-6-phosphate dehydrogenase were measured in 4 brain tumors-a glioblastoma, an astrocytoma, an ependymoma, and a psam-momatous meningioma[long dash]and in normal astrocytes, normal ependyma, and the dura mater. The enzymatic activity of astrocytes was found to be lower than that of central nervous system neuronal tissues. The activity of glucose-6-phosphate dehydrogenase was 3 to 10 times greater in all tumors, irrespective of histologic type, as compared with the analogous normal tissue.

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