Response to Progesterone of Croton Oil-Inflamed Vagina of Neonatally Estrogenized, Ovariectomized Adult Mice

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Abstract
The vaginal epithelium of 'normal' ovariectomized adult mice of the C57 Black/MS strain was strongly mucified following 10 daily injections of 1mg progesterone. In vaginae showing estrogen-independent proliferation and cornification of the epithelium of 50% of ovariectomized adult mice given neonatal injections of 20μg estradiol-17β for 10 days, the cornification was not affected by 10 daily injections of 1mg progesterone, although it was totally inhibited or intermittently interrupted by progesterone injections in the rest of animals. The vaginal epithelium was seldom mucified. In estrogenized ovariectomized mice receiving two series of 10 daily injections of progesterone at an interval, vaginal smears were similar in type during the first and second injection periods. In contrast to this, vaginal response to the second series progesterone injections was different from that to the first in 35% of mice given vaginal instillations of 0.1% croton oil for 10 days following the first series injections. Cell populations of the epithelium may be qualitatively altered in inflamed vaginae of neonatally estrogenized mice.

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